DNA hypomethylation mesured by tiling microarrays.
In the following table the methylation data from chr 21/22 tiling arrays (Schumacher et al., 2006) are available. The graphs are in a format readable by the UCSC Genome browser. The Genome Browser zooms and scrolls over chromosomes, showing the data in a seperate track next to CpG islands, CpG density, known genes and transcriptome data. By clicking on the links, the Genome browser opens automatically, displaying a specific area of chromosomes 21 or 22 (browser start position). From there, the sequence can be explored up- and downstream. The dark red graphs of the custom track on top represent the enrichment of hypo(unmethylated) DNA fragments. An example is displayed to the right. An absence of bars may represent hypermethylation of that region/CpG island.
Note: The methylation maps are relatively large, so depending on you internet speed, loading time may take up to several minutes.
Notes: All maps are based on the April 2003 version of the human genome draft. The April 2003 human reference sequence is based on NCBI Build 33. It has been released in conjunction with the International Human Genome Sequencing Consortium's announcement of the successful completion of the Human Genome Project.
This reference sequence covers about 99 percent of the human genome's gene-containing regions, and has been sequenced to an accuracy of 99.99 percent. The missing portions are essentially contained in less than 400 defined gaps that represent DNA regions with unusual structures that can't be reliably sequenced using current technology.
