This cover-story in Nucleic Acids Research received extensive world-wide feedback and was one of the most downloaded NAR papers in 2006.
Schumacher lab on the road:
Read about our study on epigenetics of late-onset Alzheimer's disease:
Have a look at our study of epigenetic changes in schizophrenia and bipolar disorder:
This study provides evidence of silencing of genes responsible for communication with the brain, brain development and other processes linked to schizophrenia and bipolar disorder.
This report was covered in several news stories around the world.
You will find here several protocols, which are used in epigenetic profiling. I tried not only to provide each step of the protocol, but also to add hints, notes, tips and tricks, making it as easy as possible to perform a successfull experiment.
DNA Methylation profiling:
Schumacher's Guide #1: Bisulfite conversion of DNA for methylation finemapping.
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Schumacher's Guide #2: Design and application of microarrays for identifying of DNA methylation.
